Education

Ph.D., Biostatistics, University of Minnesota, 2006

M.S., Electrical Engineering, University of Minnesota, 2006

M.S., Material Science, Tsinghua University, Beijing, China, 2000

B.E., Material Science, Tsinghua University, Beijing, China, 1997

 

Research Interests

• Statistical modeling in biomedical research

• Integrative analysis of high-dimensional data

• Prediction Model and biomarker discovery

• Bayesian Modeling

 

Selected Publications (Selected from more than 60)

Statistical methodology and bioinformatics

• Yun J, Wang T, Xiao G, Bayesian Hidden Markov Models to Identify RNA-Protein Interaction Sites in PAR-CLIP, Biometrics, 2014, (In Press)

• Wang T, Xie Y, Xiao G. dCLIP: a computational approach for comparative CLIP-seq analyses. Genome Biology. 2014 Jan 7;15(1):R11. PMID: 24398258

• Yang J, Wang X, Kim M, Xie Y, Xiao G., Detection of candidate tumor driver genes using a fully integrated Bayesian approach. Stat Med. 2013 Dec 18. doi: 10.1002/sim.6066. PMID: 24347204

• Xiao G, Ma S, Minna J, Xie Y., Adaptive Prediction Model in Prospective Molecular Signature-Based Clinical Studies. Clin Cancer Res. 2014 Jan 14. PMID: 24323903

• Zhong R, Kim MS, White MA, Xie Y, Xiao G. SbacHTS: spatial background noise correction for high-throughput RNAi screening. Bioinformatics. 2013 Sep 1;29(17):2218-20. Epub 2013 Jun 28. PMID: 23814141

• Xiao G, Wang X, Laplant Q, Nestler E, and Xie Y, Detection of Epigenetic Changes Using ANOVA with Spatially Varying Coefficients, Statistical Applications in Genetics and Molecular Biology, 2013 Mar 13:1-17. doi: 10.1515/sagmb-2012-0057

• Wang X, Zang M, Xiao G, Epigenetic Change Detection and Pattern Recognition via Bayesian Hierarchical Hidden Markov Models, Statistics in Medicine, 2012 Oct 25. doi: 10.1002/sim.5658.

• Wang X, Chen M, Khodursky AB and Xiao G, Bayesian Joint Analysis of Gene Expression Data and Gene Functional Annotations, Statistics in Biosciences. 2012 Nov; 4(2): 300-318.

• Allen JD, Wang S, Chen M, Girard L, Minna J, Xie Y, Xiao G. Probe mapping across multiple microarray platforms, Briefings in Bioinformatics, 2012 Sep;13(5):547-54. doi: 10.1093/bib/bbr076. PMID: 22199380

• Allen JD, Xie Y, Chen M, Girard L, Xiao G. Comparing Statistical Methods for Constructing Large Scale Gene Networks, PLoS ONE. 2012;7(1):e29348. PMID: 22272232; PMCID: PMC3260142.

• Wang S, Wang Y, Xie Y, Xiao G, A Novel Approach to DNA Copy Number Data Segmentation, Journal of Bioinformatics and Computational Biology. 2011 Feb;9(1):131-48.

• Xiao G, Wang, X, and Khodursky AB, Modelling Three-dimensional Chromosome Structure Using Gene Expression Data. Journal of American Statistician Association, 2011 106(493):61-72.

• Xiao G, Reilly C. and Khodursky, AB. (2009), Improved Detection of Differentially Expressed Genes Through Incorporation of Gene Locations. Biometrics, 65:805–814.

 

Interdisciplinary Research

• He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.Cell, 2013 Aug 29;154(5):1085-99. PMID: 23954414

• Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, Grishin NV, Peyton M, Minna J, Bhagat G, Levine B. GFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell. 2013 Sep 12;154(6):1269-84. doi: 10.1016/j.cell.2013.08.015. PMID: 24034250

• Han T, Kato M, Xie S, Wu L, Mirzaei H, Pei J, Chen M, Xie Y, Allen J, Xiao G,McKnight S. Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies. Cell, 11 May 2012 (Vol. 149, Issue 4, pp. 768-779)

• He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May H, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby, Scherer PE, Levine B, Exercise-induced Bcl-2-regulated autophagy is required for muscle glucose homeostasis, Nature, 2012 Jan 26; 481:511-515. PMID: 22258505

• Orvddahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst C, Wrana J, Zhang Y, Luby-Phelps K, Xavier R, Xie Y, Levine B. Image-Based Genome-Wide siRNA Screen Identifies Host Factors Involved in Selective Autophagy. Nature. 2011 Dec 1;480(7375):113-7. PMID: 22020285

• Wang R, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B, Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation, Science. 2012 Nov; 338(6109):956-959.

• Laplant Q, Vialou V, Covington HE 3rd, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience. 2010 Sep 13(9):1137-43.

• Renthal W*, Kumar A*, Xiao G*., Wilkinson M., Covington HE., Maze I., Sikder D., Robison AJ., LaPlant Q., Dietz DM., Russo, SJ., Vialou V.,Chakravarty S., Kodadek, TJ., Stack A., Kabbaj M., Nestler EJ. (2009) Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron, 62, 335-348. (As co-first author)

 

Contact

E-mail: Guanghua.Xiao@UTSouthwestern.edu

Office: NC08.512D

Phone: 214-648-4110

Fax: 214-648-1663