Yang Xie, M.D., Ph.D.
Director of Quantitative Biomedical Research Center, Associate Professor, Clinical Center, UT Southwestern Medical Center
Study links deficiency of cellular housekeeping gene with aggressive forms of breast cancer
Based on an analysis of two large databases on breast cancer, reduced activity of an autophagy gene, beclin 1, was related to both a higher incidence of triple-negative breast cancer and a poorer prognosis for breast cancer patients.
The study, published in the online journal EBioMedicine, is the first to document a correlation between beclin 1 and triple-negative human breast cancer and validates research in mouse models.
“Patients with breast cancer and low beclin 1 expression had a 67 percent increase in the risk of dying from breast cancer compared with patients who had higher levels of beclin 1 expression,” Dr. Xie said.