Welcome to the Dr. Lin Xu Lab.

The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases. The lab’s research works have been published in a series of high-impact journals, including Nature, Elife, PNAS, Genes & Development, Cell Reports, Nature Communications, Science Immunology, Cancer Research, Nature Machine Intelligence, Circulation Research, Clinical Cancer Research and Developmental Cell, and has received grant supports from a variety of funding resources, including the National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), National Human Genome Research Institute (NHGRI), Cancer Prevention and Research Institute of Texas (CPRIT), Hyundai Pediatric Cancer Foundation, Children’s Cancer Fund, Rally Foundation, Dysimmune Diseases Foundation and Andrew McDonough B+ Foundation.

Research

Develop NGS-based analysis algorithms and conduct integrated genomics analysis to uncover the molecular mechanisms of human diseases

Develop statistics and deep learning algorithms to build novel predictive models on drug response, clinical outcomes and other biological features for various human diseases

Develop statistical algorithms and conduct integrated genomics analysis to identify new biomarkers and therapeutic targets for human cancer

Develop statistical algorithms and conduct integrated genomics analysis to identify new biomarkers and therapeutic targets in a variety of non-cancer human diseases

Latest Publication

Chu H, et al. (2021) Protein Phosphatase 2A Activation via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circulation Research 129 (7), 735-750.

Cui M, et al. (2021) Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nature Communications 12 (1), 1-15.

Ramirez-Martinez A, et al. (2021) Essentiality of the nuclear envelope protein Net39 for nuclear integrity, chromatin organization, and muscle growth. Nature Communications 12 (1), 1-12.

Cannavino J, et al. (2021) Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Proceedings of the National Academy of Sciences USA 118 (23) e2104650118.

Bhargava V et al. (2020) GCNA Preserves Genome Integrity and Fertility Across Species. Developmental Cell. 52 (1), 38-52. e10.

Huang L, et al. (2019) SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. 569(7757):565-569.

Li S, et al. (2019) Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding. Genes & Development. 33(11-12):626-640.

Xu L, et al. (2018) Integrative Bayesian analysis identifies rhabdomyosarcoma disease genes.Cell Reports 24, 238–251.

Kendall GC, et al. (2018) PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of tumorigenesis. Elife 5;7. e.33800.

Xu L, et al. (2013) Dynamic epistasis for different alleles of the same gene. Proceedings of the National Academy of Sciences USA 109:10420-10425.

Lab News

Welcome Yuansheng Zhou to join the Xu lab!

Welcome Chen Tang to join the Xu lab!

Welcome Yanfeng Zhang to join the Xu lab!