The recent progress in studying human diseases on a genome-wide scale by NGS technologies, including whole-genome/whole-exome sequencing, RNA-seq, ribosome profiling, ChIP-seq and many others, has yielded new insights into genetic pathways and networks that reveal the molecular mechanisms of human diseases. However, the current computational algorithms still cannot effectively extract information to elucidate the molecular mechanisms of human diseases from high-throughput DNA, RNA and epigenetic sequencing data. My lab has been developing various algorithms and leading the integrated bioinformatics analyses to uncover new disease genes and pathways, and elucidate molecular mechanisms for cardiovascular diseases.
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