Pediatric Cancer Data Core

University of Texas Southwestern Medical Center
Children's Medical Center Dallas

Acknowledgement: The PCDC project is funded by CPRIT RP240521.
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PCDC Architect

PCDC architect
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PCDC Interaction with multiple groups

interaction with other groups
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PCDC Administration

user model
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Serve Pediatric Cancer Community

A data core where doctors and scientists work together to do pediatric biomedical research on digital objects such as data and analytical tools..

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Diseases

Germ Cell Tumor

Germ cell tumors (GCTs) occur in neonates, children, adolescents and young adults and can occur in the testis, the ovary or extragonadal sites.

Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL) cancer most often occurs in children ages 3 to 5 and affects slightly more boys than girls.

Neuroblastoma

Neuroblastoma develops from nerve cells in the fetus called neuroblasts.

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Use Cases

experimental therapeutics and precision medicine
experimental therapeutics and precision medicine
Pediatric cancer has been emphasized as a specific target area for advancing precision medicine into clinical care by the NCI’s Moonshot initiative. Under Stephen Skapek’s leadership, UTSW launched the Pediatric Hematology/Oncology Precision Medicine (PM) Program in 2017, and it is highly interlinked with the experimental therapeutics (ET) program. The PCDC will function as a hub to support all the components of both programs.
clinical trial
clinical trial
Investigators at UTSW/CMCD are actively engaged in clinical research through the Children’s Oncology Group and several other consortiums, maintaining a portfolio of approximately 75 clinical trials. Several UTSW/CMCD clinical researchers also express strong interest in using the PCDC to facilitate their clinical trials.
population research and cancer survivorship research
population research and cancer survivorship research
Big data and technology are starting to change the methods of population research in prevention, epidemiology, and improving quality of care in cancer survivors.
computational research
computational research
Although computational methods have made significant contributions to cancer research in recent decades, the demand for novel analytic solutions and algorithms is exceedingly high due to the heterogeneity and volume of data generated. However, accessing the high quality and rich biomedical data together with expertise are the biggest challenges for computational researchers to develop novel practically impactful computational tools.
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Research Institutions