Since 2014, my lab starts to work on developing methodology for pathology image analysis. We have collected a large amount of high-quality digital pathological data and genomic data in lung cancer. We have developed pathological image analysis pipelines for lung cancer, kidney cancer and head and neck cancer. In addition working together with investigators in Advanced Imaging Center at UTSW, my lab is actively developing statistical methods and analysis pipelines for brain imaging data, such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (TDI) data.
We are developing statistical methodologies for Bayesian analysis, spatial modeling and integrative analysis of different molecular profiling datasets.
We are actively developing new bioinformatics tools and computational algorithms for big data, such as genome-wide RNAi screening data and next-generation sequencing data.
Computational models can be used to predict patient outcomes.
I am interested in developing computational models to predict patient outcomes, which will allow clinicians to tailor treatment plans for individual patients. We have developed gene expression signatures to predict patient prognosis and response to chemotherapy. Using an innovative computational and systems biology approach, we previously identified a set of 12 genes that predicts which patients are most likely to benefit from post-surgery chemotherapy (Patent #UTSD2627). Working together with investigators at both UT Southwestern Medical Center and MD Anderson Cancer Center, we are developing a Clinical Laboratory Improvement Amendments (CLIA) -certifiable medical device and designing a prospective clinical study to translate our 12-gene predictive signature to clinical use. Relative publications:
I am devoted to apply the state-of-art statistical methods in biomedical research
Besides my research in developing statistical methodology, I am also devoted to apply the state-of-art statistical methods in biomedical research. Collaborating with top scientists at UT Southwestern Medical Center, I have co-authored more than sixty biomedical research publications, including seven publications in Nature, Science and Cell.