Central Regulation of Hepatic Metabolism

Our goal is to provide insights that will lead to improved neuromodulatory therapies for
the treatment of type 2 diabetes and non-alcoholic fatty liver disease

Central Regulation of Hepatic Metabolism

Our goal is to provide insights that will lead to improved neuromodulatory therapies for
the treatment of type 2 diabetes and non-alcoholic fatty liver disease

Central Regulation of Hepatic Metabolism

Our goal is to provide insights that will lead to improved neuromodulatory therapies for
the treatment of type 2 diabetes and non-alcoholic fatty liver disease

Introduction

At UT Southwestern Medical Center, we have assembled a multi-disciplinary and inter-departmental team of clinical and basic science investigators with diverse skills and expertise to evaluate the impact of altering the activity of the vagus nerve on hepatic metabolic pathways.

We hypothesize that manipulation of the activity of the vagus nerve holds the potential to improve glycemic control by directly altering hepatic metabolism. It is our goal to translate these insights into improved neuromodulatory therapies for the treatment of Type 2 Diabetes and non-alcoholic fatty liver disease.

Quick Links

Project 1

To generate a three-dimensional map of the vagal innervation of the liver in lean mice.

Project 2

To determine if altering the activity of vagal neurons in lean and obese mice directly affects hepatic insulin sensitivity, lipogenesis, glucose production, and substrates fluxes.

Central Regulation of Hepatic Metabolism

Central Regulation of Hepatic Metabolism

Central Regulation of Hepatic Metabolism

Central Regulation of Hepatic Metabolism (CROHM)

Introduction

Quick Links

Schematic of Proposed Studies

Projects

Project 1

To generate a three-dimensional map of the vagal innervation of the liver in lean mice.

Project 2

To determine if altering the activity of vagal neurons in lean and obese mice directly affects hepatic insulin sensitivity, lipogenesis, glucose production, and substrates fluxes.

Project 3

To determine the acute effects of vagal blockade on hepatic metabolic pathways in obese humans.