The "Data Science and Artificial Intelligence for Precision Health Initiative" (DAPHI) at UTSW is an open research platform led by faculty from the QBRC of SPH. It is designed to promote the development and application of innovative data science and AI methods specifically tailored for precision health. DAPHI brings together researchers from across the entire UTSW campus, fostering a collaborative environment devoted to biomedical data science research. Featuring three flagship programs: Real World Data Analytics, Imaging and Spatial Biology, and Computational Immunology, DAPHI is dedicated to advancing the frontiers of healthcare. By leveraging advanced data analysis and AI to analyze comprehensive health datasets, including genetic and real-time data, DAPHI seeks to create predictive models for disease forecasting and develop personalized treatment plans. This initiative is committed to discovering new health correlations, enhancing patient care, reducing healthcare costs, and improving system efficiency. DAPHI represents a significant leap towards achieving personalized, data-informed healthcare solutions, marking a new era in the way healthcare is approached and delivered.